PEGASUS™ 1.0 AI Platform, a Multimodal AI Model for Macrocyclic Peptide Design
Predictive AI & Generative AI Modules for De Novo Design & Lead Optimization of Macrocyclic Peptides
Access Application FormPEGASUS™ LoginPredictive AI Modules
Cellular Permeability
Papp (Caco-2/MDCK)
Resolution & Throughput
- PEGASUS™-HTS
- PEGASUS™-AIQM
- PEGASUS™-QM
Aqueous Solubility
[M], pH 7.4
Lipophilicity
ChromLogD7.4
calculated Lipophilic Permeability Efficiency
cLPE
Computational Chameleonicity as a Mechanism of Action (MoA) for Peptide Permeability
Peptide MoA Report
Computational Chameleonicity for Ranking Peptide Permeability
Peptide Ranking
PEGASUS™ In Vivo Stability Index™
Composite metabolic, gastric, plasma, and hepatic stability
In Vivo Oral Bioavailability
%F
Affinity
Beta
IC50
Generative AI Modules
GenAI SAR Expansion of a Peptide Lead
Papp
GenAI SAR Expansion of a Peptide Lead
Papp
+ Solubility
+Lipophilicity & cLPE
+In Vivo Stability Index™
+In Vivo Oral Bioavailability
+ Solubility
+Lipophilicity & cLPE
+In Vivo Stability Index™
+In Vivo Oral Bioavailability
GenAI SAR Expansion of a Peptide Lead
Papp
+ Solubility
+Lipophilicity & cLPE
+In Vivo Stability Index™
+In Vivo Oral Bioavailability
+ Affinity
+ Solubility
+Lipophilicity & cLPE
+In Vivo Stability Index™
+In Vivo Oral Bioavailability
+ Affinity
De novo Peptide Design
Target-agnostic, based on physicochemical properties
De novo Peptide Design
Target-Centric
Assay Automations
1910 PPA™ Massively Parallel Surrogate Permeability Assay
Generate billions of surrogate assay data points from 1910’s proprietary Permeability Proxy Assay (PPA™) for AI model training
1910 MDCK Assay Optimized for Peptides
Leverage 1910’s automated MDCK Assay Optimized for Peptides to assess cellular permeability (Papp) of macrocyclic peptides
1910 Caco-2 Assay Optimized for Peptides
Leverage 1910’s automated Caco-2 Assay Optimized for Peptides to assess cellular permeability (Papp) of macrocyclic peptides
Platform Automations
1910 PEL™
Leverage1910’s high-throughput Permeability Enhanced Library (PEL™) for novel hit finding of macrocyclic peptides
1910 mRNA Display
Leverage 1910’s high-throughput mRNA Display Platform for novel hit finding of macrocyclic peptides
1910 Phage Display
Leverage 1910’s high-throughput Phage Display Platform for novel hit finding of macrocyclic peptides
Custom Foundation Models
Build an exclusive version of PEGASUS™
that is fine-tuned/trained on your company's historical proprietary data and fine-tuned to chemical spaces of greatest interest to your company — including natural/canonical amino acids, non-canonical amino acids, chemically modified amino acids and synthetic fragments.
Predictive AI Modules
PAMPA
High-throughout in silico prediction of passive permeability of peptides
Generative AI Modules
Module X
PEGASUS™ designs macrocyclic peptides from a small molecule template and desired physicochemical properties
Module XX
PEGASUS™ designs small molecules from a macrocyclic peptide template and desired physicochemical properties
Coming Soon
PEGASUS™ 2.0
PEGASUS™ 3.0
PEGASUS™ 4.0
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Expect a reply within 1-3 business days.
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